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Tuesday, August 4, 2020 | History

3 edition of Medication development for the treatment of cocaine dependence found in the catalog.

Medication development for the treatment of cocaine dependence

Medication development for the treatment of cocaine dependence

issues in clinical efficacy trials

  • 112 Want to read
  • 18 Currently reading

Published by U.S. Dept. of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Office of Science Policy and Communications, Supt. of Docs., U.S. G.P.O., distributor] in Rockville, MD, [Washington, D.C .
Written in English

    Subjects:
  • Cocaine abuse -- Chemotherapy -- Congresses,
  • Cocaine abuse -- Treatment -- Congresses,
  • Clinical trials -- Congresses

  • Edition Notes

    Statementeditors, Betty Tai, Nora Chiang, Peter Bridge.
    SeriesNIDA research monograph -- 175., NIH publication -- no. 98-4125.
    ContributionsTai, Betty., Chiang, C. Nora., Bridge, Peter., National Institute on Drug Abuse. Office of Science Policy and Communications.
    The Physical Object
    Paginationiv, 329 p. :
    Number of Pages329
    ID Numbers
    Open LibraryOL17741009M
    OCLC/WorldCa38160933

    cocaine abuser or cocaine-dependent individual is used to refer to individu-als who meet DSM-IV criteria for cocaine abuse or dependence.) become abstinent from cocaine and other substances. The underlying assumption is that learning processes play an important role in the development and con-tinuation of cocaine abuse and dependence. An Individual Drug Counseling Approach To Treat Cocaine Addiction: The Collaborative Cocaine Treatment Study Model by Delinda E. Mercer And George E. Woody Download Book (Respecting the intellectual property of others is utmost important to us, we make every effort to make sure we only link to legitimate sites, such as those sites owned by.

    Medication Development for the Treatment of Cocaine Dependence: Issues in Clinical Efficacy Trials, ed. by Betty Tai, C. Nora Chiang, and Peter Bridge (PDF files at NIH) Items below (if any) are from related and broader terms.   Emerging drugs for the treatment of cocaine use disorder: a review of neurobiological targets and pharmacotherapy. Expert Opin Emerg Drugs. ; 4. Liu S, Green CE, Lane SD, et al. The influence of dopamine β-hydroxylase gene polymorphism rs on levodopa/carbidopa treatment for cocaine dependence: a preliminary study.

      The purpose of the current study is to re-examine results from two prior studies (McKay et al., ; Stulz et al., , using data from the NIDA Collaborative Cocaine Treatment Study) which reported that depression was associated with relatively poorer outcomes in the treatment of cocaine dependence in order to test the hypothesis that.   Cocaine Treatment and Rehab. Cocaine is a dangerous and addictive drug, but with proper treatment, recovery is possible. Treatment for cocaine addiction involves detox, medications, and therapy, and it works best with support from family, friends, and professionals.


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Medication development for the treatment of cocaine dependence Download PDF EPUB FB2

Once a person enters cocaine addiction treatment, maintaining abstinence over the long-term requires the type of commitment and motivation that many recovering addicts just can’t muster.

The damaging effects of cocaine strip away a person’s will and motivation making it all the more difficult to stay off drugs. This chapter focuses on opiates and cocaine, the two classes of drugs targeted by the National Institute on Drug Abuse (NIDA) Medications Development Division (MDD), and begins with an overview of the various concepts of addiction that influence not only the current addiction-treatment methods, but also the scientific investigation of current and potential pharmacological approaches to : Carolyn E.

Fulco, Catharyn T. Liverman, Laurence E. Earley. The development of pharmacological agents to manage cocaine dependence has been a long sought-after goal of the National Institute on Drug Abuse’s (NIDA) Medications Development Program.

Despite several years of testing, there is no FDA-approved medication for the treatment of cocaine dependence. However, that may change in the coming years. What it does: An amino acid that curbs cocaine cravings and repairs damage in the brain caused by cocaine use in animals How it works: Restores glutamate levels to normal in the area of the brain where addiction occurs Side effects: Gastrointestinal disturbance, diarrhea, nausea, vomiting, fatigue, skin rash For a more complete list of side effects see this web page.

In addition, development of treatments for cocaine dependence has been complicated by the tendency for abusers not to complete treatment programs and their propensity for relapse.

Despite these challenges, some treatment approaches, such as cognitive behavioral therapy (CBT) and medications have shown promise in successfully treating cocaine. meeting "Medications Development for the Treatment of Cocaine Dependence: Issues in Clinical Efficacy Trials," which was held in October at NIDA.

The Medication development for the treatment of cocaine dependence book at this Technical Review were arranged into three sessions. The first session provided an overview of the rationale for pharmacotherapeutical approaches and a.

Books. An illustration of two cells of a film strip. Video An illustration of an audio speaker. Medication development for the treatment of cocaine dependence: issues in clinical efficacy trials insights from basic and clinical research -- Overview of potential treatment medications for cocaine dependence -- Methodologic.

Exclusion criteria included dependence on a drug other than cocaine, marijuana or nicotine, or physiological dependence on alcohol requiring medical detoxification.

Some other exclusions were: serious medical illness including AIDS, psychiatric or neurological disorder requiring (pharmacologic) treatment, pregnancy or lactation, and court. Anti-cocaine Vaccines. Anti-cocaine vaccines began to be made in The first report, by Bagasra (), used questionable chemistry to create the vaccine (), but the door wasJanda prepared the first credible anti-cocaine vaccine ().A hapten (named GNC) with a six-carbon linker terminating in a carboxylic acid group was synthesized starting with BE and.

Pharmacotherapy for the treatment of drug addiction11Drug addiction is defined as the compulsive use of a drug despite adverse consequences. This report focuses on opiate and cocaine addictions and does not address alcohol and nicotine addictions.

has received far too little attention, despite the clinical success of methadone, which dates back to the s.

Over the last 30 years only two additional medications have been approved for the treatment of opiate addiction, naltrexone and levo-alpha-acetylmethadol (LAAM), and it is important to note that both of those medications were developed in the s and early s.

There is no approved medication for the treatment of cocaine addiction. Philadelphia, PA, Novem – Medication development efforts for cocaine dependence have yet to result in an FDA approved treatment. The powerful rewarding effects of cocaine, the profound disruptive impact of cocaine dependence on one’s lifestyle, and the tendency of cocaine to attract people who make poor life choices and then exacerbate impulsive behavior all make cocaine.

The limited number of medications approved for the treatment of heroin dependence and the lack of medications approved for the treatment of cocaine dependence suggest many obstacles that must be overcome in developing drug treatments for these indications.

Beyond the inherent difficulty of translating preclinical data into clinical efficacy. XV11 Additional Cost of Reducing Cocaine Consumption by One Percent with Alternative Cocaine-Control Programs, 1 14 Narcotics for the Treatment of Narcotic Addiction are a Legally-Defined Subset of Narcotics and Controlled Substances, Payments for Methadone Treatment, All Types of Drug Abuse Treatment, and All Types of Health.

Get this from a library. Medication development for the treatment of cocaine dependence: issues in clinical efficacy trials. [Betty Tai; C Nora Chiang; Peter Bridge, M.D.; National Institute on Drug Abuse. Office of Science Policy and Communications.;]. While no medication has received regulatory approval for the treatment of cocaine dependence, several medications marketed for other indications have shown efficacy in clinical trials.

An anti-cocaine vaccine and several compounds in preclinical development have also shown promise. Cocaine Addiction Treatment. Cocaine is one of the most widely available drugs in the United States. It can be found in communities both large and small, ripping families apart causing financial ruin, relationship problems, health problems a wide world of consequences for the user and for others who are indirectly involved.

Medication development for the treatment of cocaine dependence: issues in clinical efficacy trials / By Peter. Bridge, Nora. Chiang, Betty. Overview of potential treatment medications for cocaine dependence -- Methodologic recommendations for cocaine abuse clinical trials: a clinician-researcher's perspective -- Management of clinical.

So far, there are no FDA-approved medications for the adjunctive treatment of cocaine dependence. However, several compounds have shown evidence of efficacy in preliminary studies (Vocci et al., ).

Disulfiram, used for treating alcohol dependence, may also have efficacy in cocaine treatment by altering brain dopamine activity through an. This book is recommended as a textbook on cocaine addiction for psychiatrists who work mostly with chemically addicted patients and as an authoirative source book for general psychiatrists who may from time to time seek a quick reference on cocaine addiction.

After reading this book, the clinician can better understand or handle his or her next Format: Hardcover. A grant of up to $ million from a National Institutes of Health program has positioned a Winston-Salem biotech company studying chemical compounds to treat cocaine addiction closer to its goal.

A promising new drug treatment for cocaine addiction has been discovered by researchers. The experimental therapy, which involves administering a drug currently used in cancer therapy trials.

Inthe Committee on the Problems of Drug Dependence awarded him the Cochin Award for his contributions to the development of medications to treat substance abuse. He is an editorial board member on a number of professional journals and has published over papers, books, and : Hardcover.